KPV
α-MSH-derived tripeptide for melanocortin and inflammatory signaling research.
This lyophilized peptide must be reconstituted with RECON-S before use in research. Most customers forget to add it — don't get stuck waiting for a second order.
Add Reconstitution SolutionKPV (Lysine-Proline-Valine) is a naturally derived tripeptide representing the C-terminal fragment (positions 11–13) of alpha-melanocyte-stimulating hormone (α-MSH). At approximately 342 Da, it is among the smallest bioactive peptides studied for immune modulation, and its compact structure confers metabolic stability advantages over larger peptide research compounds.
A key research distinction: KPV separates the anti-inflammatory activity of the parent α-MSH molecule from its melanogenic effects. Binding studies have shown KPV lacks significant affinity for MC1R-mediated cAMP elevation — the classical second messenger of melanocortin pigmentation signaling — making it a useful tool for isolating immunomodulatory pathway activity in controlled laboratory settings.
